Open access
Sep 2026
The nematode Caenorhabditis elegans has a cationic amphiphilic drug (CAD) defense system
Cationic Amphiphilic Drugs (CADs) severely disrupt lysosomal function, which leads to a cellular pathology in humans characterized by excess phospholipids called phospholipidosis. Through a forward genetic screen and mining of published datasets, we discovered that CADs induce the expression of the CYP-35B family of cy...
Levon Tokmakjian, Duhyun Han, Kateryna Sihuta et al.
· PLoS Biology · 0 citations