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Author

Marjorie Rolland

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Review Sep 2026

Abstract B041: MEK/ERK-dependent regulation of TFEB in response to chemotherapeutic stress

Our previous studies identified Transcription factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, as highly expressed in pancreatic cancer (PDAC) cells, where it exhibits prominent nuclear localization even under basal conditions. Functional studies demonstrated that TFEB depletion in PDAC cel...

Marie-Josée Boucher, Marjorie Rolland · 0 citations
Open access Jul 2026

Msh2 depletion impairs cell differentiation, proliferation and metabolism in esophageal organoids.

Evaluated effects of Msh2 loss on stem cell functions, including differentiation, clonogenicity, and proliferation, in murine esophageal organoids showed that Msh2 is implicated in the homeostasis of esophageal organoids, potentially through metabolic rewiring.

Marjorie Rolland, D. Jean, M. Hamilton et al. · 0 citations

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