Author

Mark A. Atkinson

2 papers indexed here

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Open access Aug 2026

Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

These studies identified novel mechanisms of β-cell dysregulation before symptomatic onset and independent of T-cell infiltration in T1D pathogenesis.

Alexandra E. Cuaycal, Elizabeth A. Butterworth, Scott E. Stimpson et al. · bioRxiv · 0 citations

Open access Sep 2026

Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes

Effector CD8+ T cells are key drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, peripheral tissue phenotype, and receptor specificity. We analyzed human pancreatic lymph nodes (pLNs) using mass cytometry and single-cell RNA-seq (scRNA-se...

Leeana D. Peters, Howard R. Seay, Justin A. Smith et al. · Journal of Clinical Investig... · 1 citation