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Author

Mark D. Krieger

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3 papers indexed here

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Sep 2026

Optimizing acquisition of cerebrospinal fluid liquid biopsy for next-generation sequencing in pediatric central nervous system tumors.

OBJECTIVE Best practices for obtaining adequate cell-free DNA (cfDNA) for next-generation sequencing (NGS) are not currently well understood. This study aimed to improve the understanding of appropriate quantities of CSF extraction from an array of tumor types and locations that could be used for diagnosis of pediatric...

Nicholas Chapman, Peter A. Chiarelli, Katrina O'Halloran et al. · 0 citations
Oct 2026

Quantitative MRI to assess baseline shunt flow in patients with hydrocephalus: a noninvasive tool to aid clinical decision-making.

OBJECTIVE Hydrocephalus is a common yet serious condition, and ventricular shunts are used for lifesaving CSF diversion. Existing methods for shunt evaluation provide correlative/qualitative information, leading to commonplace clinical diagnostic challenges. The aim of this study was to determine accurate and noninvasi...

Joseph H. Ha, Madison E. Gutierrez, Jason M. Toliao et al. · 0 citations
Oct 2026

Optimization of phase-contrast MRI shunt flow measurement across multiple scanners for the management of hydrocephalus.

OBJECTIVE Ventricular shunts divert CSF in patients with hydrocephalus, often providing lifesaving intervention. Untreated shunt failure can lead to increased intracranial pressure and subsequent neurological injury. Phase-contrast MRI (PC-MRI) is a noninvasive technique to assess shunt function by measuring shunt flow...

Jason M. Toliao, Matthew T. Borzage, C. González-Zacarías et al. · 0 citations

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