This work identifies Gim3, a subunit of the ubiquitously expressed and conserved prefoldin complex, as a critical regulator of meiotic but not mitotic chromosome segregation in budding yeast and reveals an exciting and previously unrecognized link between chromosome segregation and meiotic cellular remodeling.
Naohiro Kuwayama, Benjamin S. Styler, Bojana Stekovic et al.· Science Advances· 0 citations
It is found that the endogenous UPR that precedes meiosis in budding yeast is required for gamete production but diverges dramatically from previously defined UPR outputs, with only a few characterized UPR targets induced, and mildly.
Constantine Bartolutti, Alena L. Bishop, Yanzhe Ma et al.· Journal of Cell Biology· 0 citations
The use of site-specific photo-crosslinking to covalently capture the substrates of tyrosine phosphatases in situ reveals previously unknown roles of PTP1B in signaling systems and could be readily extended to other tyrosine phosphatases in the same family.
Andrew C. Johns, Yethmie S. Goonatilleke, David C. Cabanero et al.· bioRxiv· 0 citations
It is shown that ARID5A regulates RNA processing in microglia, linking immune and lysosomal pathways to iron-driven death in neurodegeneration and highlighting the importance of protein-RNA interactions in regulating microglial cell biology.
Danielle M. Schafer, Steven M. Blue, Shu-Hao Xu et al.· Nature Communications· 0 citations
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