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Author

Marko Tvrdic

2 papers indexed here

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#machine learning Preprint Oct 2026

Cross-species representation learning aligns mouse and human neural dynamics and tracks clinical drug efficacy

Preclinical models poorly predict human drug efficacy, particularly in neurological disorders. Neural activity offers a uniquely rich source of translational information because it captures high-dimensional variation in nervous-system function that can be measured in both animals and humans. However, its high dimension...

Marko Tvrdic, J. Domingo, Jae Ann Buenaluz et al. · 0 citations
#artificial intelligence Preprint Oct 2026

CircuitATLAS: Agentic reasoning over a systems neuroscience knowledge graph for target discovery in circuitopathies

CircuitATLAS provides a framework for discovering therapeutics based not only on what is molecularly disrupted in disease, but on what can be controlled to restore circuit function, and introduces a human-governed in vivo lab-in-the-loop linking hypothesis generation to experimental iteration.

Gabriel Ocana-Santero, Marko Tvrdic · 0 citations

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