Simple Summary When cancer is diagnosed in a child, it is essential to determine whether it has spread to other parts of the body, because this influences treatment and the chances of recovery. Positron-emission tomography combined with computed tomography is a common diagnostic test that is used for this purpose. Howe...
André Lollert, Maximilian Wittmann, F. Souschek et al.· Cancers· 0 citations
We develop blinded sample size re-estimation strategies for McNemar's test based on paired binary primary and secondary short-term surrogate endpoints. The development is motivated by a prospective randomized clinical trial on childhood glaucoma. A conditional power expression for McNemar's test given the primary endpo...
Markus Schepers, W. Brannath, Esther M. Hoffmann et al.· 0 citations
The emergence of Post-COVID sequelae (PCS) represents a global challenge. However, understanding of biological mechanisms and the definition of quantifiable risk factors remains limited. This study employed machine learning-based classification to explore the potential of proteomics in identifying associations with ind...
Sepehr Golriz Khatami, Rieke Baumkötter, T. Köck et al.· Molecular & Cellular Proteom...· 0 citations
The COVID-19 pandemic profoundly disrupted public health, social systems, and the workforce. This longitudinal study examines changes in depressive and anxiety symptoms before and during the pandemic in middle-aged and older adults (N = 6,813) from the Gutenberg Health and Gutenberg COVID-19 Study in Germany. Using rep...
T. Beutel, N. Hettich-Damm, Julia Petersen et al.· Frontiers in Public Health· 0 citations
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