Open access
Aug 2026
Natural Metabolites from Tabebuia aurea Reveal Isoform-Specific and Cooperative Modulation of Cathepsins B and L.
It is demonstrated that structurally simple phenolic compounds can induce fundamentally different inhibition mechanisms in closely related enzymes, establishing a structure-mechanism framework for isoform-selective modulation of cysteine proteases.
Marli de Fátima Corrêa Emiliano, Mariele R. S. Gonçalves, L. M. R. de Novais et al.
· Archives of Biochemistry and... · 0 citations