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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Marloes A. M. Pennings

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Open access Aug 2026

14-3-3/Tau molecular glues modulate in vitro tau condensation

The intrinsically disordered protein Tau is highly phosphorylated under pathological conditions, which, among others, results in Tau liquid–liquid phase separation (LLPS), followed by aggregation. The hub protein 14-3-3 regulates Tau protein solubility and prevents LLPS by binding with phosphorylated Tau residues pS214...

Maxime C. M. van den Oetelaar, Leandre M. Ravatt, Francisco Maqueda Zelaya et al. · 0 citations
Open access Sep 2026

C-RAF Sequence-Encoded Cooperativity Hotspots for 14-3-3/C-RAF Molecular Glues

14-3-3 Proteins are hub proteins with an extensive interactome of phosphorylated client proteins, making them attractive targets for molecular glues (MGs) that stabilize specific 14-3-3/client protein complexes. However, selectively stabilizing individual 14-3-3 protein−protein interactions (PPIs) remains a key chall...

Marloes A. M. Pennings, G. Lauffer, Markella Konstantinidou et al. · 0 citations

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