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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Marta Dudek

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Open access Oct 2026

Function-preserving photooxidation of AS1411 aptamer by a G-quadruplex-guided photosensitizer

AS1411 is a G-quadruplex (G4) aptamer that binds nucleolin (NCL) and is widely used to promote cancer-associated delivery of photoactive cargos. Yet the fate of AS1411 after photosensitizer loading and light activation remains unclear as reactive oxygen species (ROS) generation could disrupt its guanine-rich fold and a...

Maria V. Cottini, Karolina Saczuk, Jakub Trojnar et al. · 0 citations
Open access Aug 2026

G-quadruplex DNA reprograms the photochemistry of CX-5461 toward radical-driven anticancer activity

In vivo, light-activated CX-5461 suppresses tumor growth and extends survival in immunocompetent syngeneic models, eliciting hallmarks consistent with immunogenic genome stress, and supporting a model in which broader oxidative DNA damage may also contribute to the biological response.

Jakub Trojnar, M. V. Cottini, Marta Dudek et al. · 0 citations

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