Ion modulation restores local synaptic function in APOE4 neuronal networks despite persistent impairments in global network organization
The apolipoprotein E ε4 (APOE4) allele is the strongest genetic risk factor for developing sporadic Alzheimer’s disease (AD), which accounts for the vast majority of AD cases. Ion dysfunction has emerged as a central mechanism involved in APOE4-related pathology, reflecting the importance of ion homeostasis for cell me...