Author

Martin M. Reich

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Case report Open access Sep 2026

Targeting the Subthalamic Nucleus in MEGDEL Syndrome: A Case Report of a Clinically Effective Intervention for Debilitating Lingual Dyskinesia and Dystonia

Mitochondrial diseases exhibit heterogeneous pathophysiologies and phenotypes that, depending on severity, may substantially impair health, development, and life quality. This heterogeneity makes accurate disease-speci ﬁ c treatment indispensable. This applies in particular to MEGDEL syndrome (associated with mutations...

Philipp Köberle, F. Lange, Ghadir Abbas et al. · Movement Disorders Clinical... · 0 citations

Open access Oct 2026

Non-motor symptoms burden and motor recovery following STN–DBS in Parkinson's disease: a data-driven longitudinal analysis

Subthalamic nucleus–deep brain stimulation (STN–DBS) reliably improves cardinal motor symptoms in Parkinson's disease (PD). However, gait disorders and non-motor symptoms (NMS) may persist or emerge following surgery, diminishing quality of life and complicating clinical management. To characterize the dominant axes of...

Ghadir Abbas, Robert Peach, U. Temuulen et al. · Journal of Neurology · 0 citations

#generative ai Review Open access Sep 2026

Real-world use and evaluation of a generative AI chatbot for Parkinson's disease information: a prospective observational study

Summary Background Patient-facing medical AI chatbots are entering clinical use faster than evidence can characterise their real-world safety. We evaluated one deployed system and introduce CARE-LLM, a proposed framework for conversation-level post-market surveillance. Methods We conducted a prospective, observational,...

Florian Lange, Ssaman Mardi, T. Binder et al. · The Lancet Regional Health -... · 0 citations