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Author

Martin Okitwi

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Open access Aug 2026

Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda

W Whole-genome sequencing of clinical isolates of Plasmodium falciparum in Uganda reveals rapid selection of a PX1-associated haplotype linked to reduced susceptibility to commonly used antimalarials.

K. Niaré, Bersabeh Tafesse, Mayland Treat et al. · 2 citations

Structure − Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors

Cryo-EM structural studies reveal a novel binding pose of the inhibitor at the Pf 20S β 5 active site, explaining the enhanced activity of an N -cap sulfonamide modification compared to an N -cap amide, and offer insights into the development of next-generation antimalarial Pf 20S-targeting compounds with improved drug...

Hao Zhang, Da-Qiang Li, Hao-Chi Hsu et al. · 0 citations

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