Martin R. Larsen

Phosphorylation-dependent control of transcription factor activity regulates temporal patterning of cortical cell fate specification

The development of the cerebral cortex requires precise temporal control of transcription factor (TF) activity to coordinate neuronal and glial lineage transitions. However, the molecular mechanisms coupling signaling dynamics to TF function remain unclear. Here, we combine proteomic, phosphoproteomic, and multi-omic...