Aug 2026
Should I Stay or Should I Go-Leveraging an Overlooked Feature of Click-to-Release Chemistry for Affinity Labeling.
Click-to-release (C2R) chemistry is widely used for controlled payload liberation, yet the reactivity of its transient intermediates has remained largely unexplored. Here we show that an intermediate formed during the reaction of trans-cyclooctene (TCO)-appended protein-targeting ligands with release tetrazines (rTzs),...
Dóra Kern, K. Németh, T. Imre et al.
· Angewandte Chemie · 2 citations