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Author

Marvin Hering

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Open access Sep 2026

IFNAR1-dependent metabolic circuit drives pathogenic neutrophil activation in chronic mucosal inflammation

A conserved IFNAR1-driven circuit mediated by iron homeostasis that sustains neutrophil pathogenicity across distinct mucosal tissues is defined and a targetable metabolic node for selectively disarming pathogenic neutrophil responses in the setting of chronic inflammatory disease is identified.

Cecilia Pessoa Rodrigues, Raquel R. Calçada, M. Arnaud et al. · 0 citations

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