Open access
Sep 2026
Combinatorial action of regulatory systems generates colistin heteroresistance
The mechanism by which phenotypic heterogeneity is generated within a bacterial population and leads to colistin heteroresistance has been unclear. Heteroresistance is a form of antibiotic resistance in which a minor subpopulation of resistant cells coexists with a majority susceptible population. Colistin heteroresist...
Jacob E. Choby, E. Crispell, Mu-Qing Ma et al.
· Science Advances · 0 citations