Author

Maryam Elsayed

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Open access Sep 2026

Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries

These findings identify age-associated loss of GPR81 as a driver of vascular metabolic dysfunction and cellular senescence and establish pharmacological GPR81 activation as a promising therapeutic strategy for preserving vascular homeostasis and mitigating age-associated cardiovascular disease.

Yu-Lun Wu, Hamsa Vardini Senthil Kumar, Sai Harsha Bhamidipati et al. · bioRxiv · 0 citations

Open access Aug 2026

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

It is reported that loss of the lactate receptor GPR81 in cellular and progeroid models of muscle aging is associated with impaired lipid oxidation and enhanced lipid accumulation, and agonists of GPR81 might play a promising role in reversing age‐associated lipid accumulation and loss of muscle function.

Pihu Mehrotra, Sai Harsha Bhamidipati, P. Lei et al. · Aging Cell · 0 citations