Author

Masaki Terabe

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Open access Sep 2026

Structure-based analysis reveals a hydrophobic pocket governing P2Y12 receptor agonist potency and selectivity.

Agonist of the ADP-activated P2Y12 receptor modulate platelet aggregation and microglial function, yet the structural basis of their potency and selectivity remains unclear. Using recent active-state cryo-EM structures of P2Y12 and P2Y1 receptors, we applied an integrated modelling approach to revisit a structurally un...

Matteo Pavan, Jih-Yun Lee, John C. Hancock et al. · Journal of Enzyme Inhibition... · 0 citations

Open access Sep 2026

A novel sulfatide analog recognized by human iNKT cells enhances polyfunctional antigen-specific CD8+ T cell responses

Invariant natural killer T (iNKT) cells are CD1d‐restricted T cells that recognize lipid antigens. Studies of analogs of a prototypic iNKT cell antigen, α‐galactosylceramide (α‐GalCer), have shown that ceramide structure affects the activities of mouse iNKT cells recognizing the antigen. However, the impact of antigen...

Ayaka Hara, Julia DiSapio, Morgan Coombs et al. · European Journal of Immunolo... · 0 citations

Open access Aug 2026

Cancer-intrinsic SIRPα Signaling Triggers Mitochondrial Fission and Immune Tolerance to Promote TNBC Breast-to-Brain Metastasis.

BACKGROUND Triple negative breast cancer (require) new treatment strategies due to poor responses to current therapies. While myeloid SIRPα mediates immunosuppression, its cancer intrinsic role remains poorly understood. METHODS Human breast cancer scRNAseq profiles were used to examine SIRPα expression across differ...

Yu-Ting Tsai, Jessica D. Mackert, Adam S. Wilson et al. · Neuro-Oncology · 0 citations