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Author

Masaru Miyagi

2 papers indexed here

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Open access Oct 2026

53BP1 condensates regulate DNA replication progression and completion.

DNA replication in mammalian cells proceeds in chromosomal domains during defined windows of S phase; however, the mechanisms coordinating replication with restoration of chromatin states remain incompletely understood. Here, we identify p53-binding protein 1 (53BP1) condensates as regulators of heterochromatin replica...

Fang-Fang Wang, Xin-Ran Geng, Jun-Qiu Zhang et al. · 0 citations
Open access Sep 2026

Structural insights into ligand-induced CARD assembly in inflammatory caspases

Abstract Non-canonical inflammatory caspases detect cytosolic lipopolysaccharide (LPS) through its caspase activation and recruitment domain (CARD), yet how ligand binding drives higher-order CARD assembly remains poorly understood. Here, we identify CBM7, a minimal SERPINB1-derived peptide, that induces caspase-4 CARD...

Jae U. Jung, Zhong-Yi Jiang, Junbae Park et al. · 0 citations

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