Author

Masato T. Kanemaki

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Open access Sep 2026

Quantitative changes in 3D contact predict changes in enhancer-promoter regulation upon cohesin depletion

Enhancers are drivers of gene regulation thought to act via 3D interactions with promoters. However, genome-wide cohesin depletion causes only limited changes in gene expression, despite widespread loss of contact domains, raising questions about how 3D contacts and cohesin influence enhancer function. Here, we intro...

Philine Guckelberger, Benjamin R. Doughty, Suhas S. P. Rao et al. · Nature Communications · 0 citations

Open access Sep 2026

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. Here, to address this question, we combine...

Masa A. Shimazoe, Shiori Iida, Katsuhiko Minami et al. · Nature Genetics · 12 citations