Identification of novel HIV-1 capsid protein (CA) inhibitors (ACAi-010 and ACAi-024) that promotes hyper-stabilization of HIV-1 CA in vitro.
The human immunodeficiency virus type 1 (HIV-1) capsid protein (CA) is a vital viral component and an attractive antiviral target. Our prior research demonstrated that amino acid (AA)-inserts at certain positions within the HIV-1 CA result in significant CA degradation, and that such AA-insert-containing HIV-1 have sig...