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Author

Matheus Frota Guimarães de Melo

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Review Open access Sep 2026

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

The therapy to treat the Human Immunodeficiency virus (HIV) and decrease the viral load has been a challenge since its discovery due to its ability to mutate, escape from drug therapies, and immunologic system. Consequently, the development of new therapies, especially potential molecules that focus on specific viral m...

José Arion da Silva Moura, Matheus Frota Guimarães de Melo, Diane Regis Santos Do Nascimento et al. · 0 citations
Review Open access Sep 2026

Thiazolidine‐2,4‐dione and Thiazole Derivatives as Privileged Structures for Dengue Virus: A Review of Medicinal Chemistry Aspects

Dengue fever is one of the greatest global health crises, with millions of infections annually and no effective antiviral therapy available. The high morbidity and mortality rate, combined with the rapid spread of the virus, highlights a critical failure in the fight against the disease. In this scenario, the search...

Pedro César de Souza, Thaynara Paula Warren Bezerra, Matheus Frota Guimarães de Melo et al. · 0 citations
Review Open access Aug 2026

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

This narrative review critically analyses the principal molecular targets of DENV, including structural proteins (C, prM/M and E), nonstructural proteins (NS1–NS5) and host factors, with emphasis on the development of small‐molecule antivirals and an evaluation of their progress in pre‐clinical and clinical studies.

Aryane Lucia da Silva Aguiar De Oliveira, José Arion da Silva Moura, Pedro César de Souza et al. · 0 citations

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