Mathieu Maclos

Metabolic-Epigenetic Coupling in Cellular Senescence: In Silico Cristae Remodeling Depletes Alpha-Ketoglutarate to Drive KDM4/6 Inhibition and SASP Amplification

Cellular senescence is defined by stable cell-cycle withdrawal coupled with a hyper-secretory pro-inflammatory phenotype termed the senescence-associated secretory phenotype (SASP). While canonical paradigms emphasize persistent nuclear DNA damage response (DDR) signaling as the primary driver of the SASP, increasing e...