Open access
Aug 2026
Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis.
It is shown that stress granules (SGs) formation is a key adaptive mechanism enabling pancreatic cells to tolerate oncogenic KRAS signaling, and SGs inhibition does not affect pancreatic damage during chronic pancreatitis, supporting its safety for selectively targeting KRAS-mutant cells.
Matías Estarás, Emma Cosialls, Gareth Pollin et al.
· Cell Reports · 0 citations