Open access
Sep 2026
Impact of Trastuzumab and Pertuzumab on HER2 Localization and the Estrogen Receptor Cistrome in ER+/HER2+ Breast Cancer
Background Although anti-HER2 monoclonal antibody therapy with trastuzumab and pertuzumab is highly effective for HER2-positive breast cancer, co-expression of estrogen receptor (ER) significantly reduces pathologic complete response rates. Objective We investigated how HER2-targeted inhibition affects HER2 cellular lo...
Stanley Tam, S. Bahnassy, Lu Jin et al.
· bioRxiv · 0 citations