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Author

Matthew E. Spector

2 papers indexed here

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Open access Oct 2026

Spatiotemporal Heterogeneity of HPV Integration Architectures Drive Oncogenic Features of Oropharyngeal Cancer

Viral integration is common in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC), but its structural and clinical significance remains unclear. We integrated targeted capture sequencing of 197 HPV+ OPSCCs with long-read nanopore sequencing of 17 tumors and models to characterize HPV–host...

Wen-Jin Gu, A. Bhangale, Xiao-Meng Du et al. · 0 citations
Review Open access Sep 2026

Challenges in the detection and assembly of virus integration structures in human genomes

This study systematically reviews sequencing platforms and their application for detecting structural variants and evaluates long-read assembly tools for reconstructing HPV integration structures, enabling a more comprehensive understanding of virus-driven genome remodeling in cancer.

Xin-Yi Deng, Xiao-Meng Du, E. Gensterblum-Miller et al. · 0 citations

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