Author

Matthew H. Thomas

3 papers indexed here

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Open access Aug 2026

Intranasal delivery of a COBRA-based protein vaccine adjuvanted with c-di-AMP enhances breadth of protective immune responses against seasonal influenza viruses

Seasonal influenza vaccines provide variable protection against antigenically drifted influenza A (H1N1 and H3N2) and influenza B viruses. Broadly protective approaches using computationally optimized broadly reactive antigens (COBRAs) can enhance immunity against diverse strains. Bis-(3′,5′)-cyclic dimeric adenosine m...

Camila C. S. Caetano, David A. Prots, Matthew H. Thomas et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

Computationally Optimized H1 and H3 Hemagglutinin Messenger RNA Vaccines Confer Broad Protective Immunity Against Modern Influenza Viruses

The hemagglutinin (HA) glycoprotein of seasonal influenza viruses undergoes continual antigenic drift, contributing to vaccine mismatch and reduced effectiveness of strain-specific seasonal vaccines. Although vaccination remains the most effective strategy for preventing influenza disease, conventional egg-based vaccin...

James D. Allen, Jessica M. Medina, Camila Caetano et al. · bioRxiv · 0 citations

Open access Aug 2026

Design and characterization of broadly protective influenza A(H3N2) vaccine candidates using protein language models

It is demonstrated that an integrated generation–selection strategy can enhance vaccine coverage across current and future A(H3N2) seasons and may be applicable to other influenza subtypes.

Victoria R. Howard, James D. Allen, Matthew H. Thomas et al. · bioRxiv · 0 citations