Author

Matthias D. Koch

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Open access Sep 2026

Pil-Chp orchestrates a multi-level regulatory system to control type IV pilus dynamics in Pseudomonas aeruginosa

The cyclical extension and retraction dynamics of type IV pili (T4P) mediate critical virulence traits in many bacterial species, yet how these dynamics are regulated remain poorly understood. Here, by analyzing individual pilus dynamics across mutants covering the entire T4P system of Pseudomonas aeruginosa, we identi...

Farhana Haque, Zil K. Modi, Lincon Mazumder et al. · bioRxiv · 1 citation

Open access Jun 2026

Machine Learning-Guided Discovery of Bacterial-Selective Membrane-Active Compounds Reveals Mechanistic Bias in Antibiotic Training Datasets

The rise of antibiotic resistance necessitates the discovery of antibacterial compounds with novel mechanisms of action (MoAs). Recent machine learning approaches have shown promise in antibacterial compound discovery, but often identify derivatives of known antibiotic classes rather than mechanistically novel compound...

Connor Chain, Soodabeh Ghaffari, Syrine Belakaria et al. · bioRxiv · 0 citations