Open access
Aug 2026
Combined Plasmid Redesign and Transfection Optimization Significantly Increases Upstream AAV Titers While Maintaining Vector Quality and In Vivo Potency
Across multiple AAV capsids and independent production runs, the optimized process reproducibly increased crude harvest titers by approximately 10- to 33-fold relative to the standard process, while maintaining key vector quality attributes.
Shiliang Hu, Yinxin Chen, Carmen Wu et al.
· Microorganisms · 0 citations