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Author

Matthias Mack

2 papers indexed here

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Open access Oct 2026

Interferon-λ inhibits immunopathology and boosts T cell–mediated immunity in a mouse model of mucosal viral infection

Interferon lambda (IFN-λ) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal delivery of IFN-λ abrogates the herpes simpl...

Emily Feng, Alexa Mansour, Elizabeth Balint et al. · 1 citation
Aug 2026

CAR T cell-derived TNF is an early determinant of cytokine release syndrome severity.

Cytokine release syndrome (CRS) is a common and potentially severe toxicity of chimeric antigen receptor (CAR) T cell therapy, characterized by activation of the host myeloid compartment and systemic inflammation. Although downstream effectors such as interleukin-6 (IL-6) and IL-1β are well-characterized, the upstream...

P. Lindenbergh, Theodoros Giavridis, Ophélie Vivier et al. · 2 citations

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