Matthias Magoola

Computational design and translational development of TCR-mimic scFv antibodies for peptide-HLA neoantigen targeting

Single-chain variable fragments (scFvs) penetrate tissue more effectively than full antibodies and are simpler to produce, but the mutant proteins that define a tumor are predominantly intracellular and therefore inaccessible to conventional antibodies. What is accessible is the mutation-derived peptide displayed on ce...