Author

Matthias Mann

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Open access Sep 2026

AlphaPeptTools: scverse-native analysis of mass spectrometry-based proteomics

Mass spectrometry (MS)-based proteomics now routinely profiles proteomes at scale, but extracting biological insight and integrating complementary modalities remains challenging. Here, we present AlphaPeptTools, a Python package for the analysis of MS-proteomics data built on the AnnData data structure of the scverse....

Vincenth Brennsteiner, L. Diedrich, S. Ben-Moshe et al. · bioRxiv · 0 citations

Open access Jul 2026

Machine learning-guided discovery of a conserved plasmid proteomic signature enables MALDI-TOF MS detection of pOXA-48-carrying Enterobacterales

This approach reframes the resistance prediction task from inferring a resistance phenotype to detecting a conserved plasmid through its expressed proteomic signature and has the potential to enable rapid MALDI-TOF MS-based diagnostics for a wide range of plasmid-based resistance determinants.

Janko Sattler, J. Mueller-Reif, Dexiong Chen et al. · bioRxiv · 0 citations