Mattia Trapella

Rational Polyligand Design for G‑Quadruplex Multimer Stabilization

G-quadruplexes (G4) are noncanonical nucleic acid secondary structures formed by guanine-rich sequences that can form higher-order multimers under appropriate conditions and represent attractive targets for multivalent molecular recognition. Here, we propose a rational ligand design strategy based on multivalency, in w...