Open access
Sep 2026
Checkpoint kinase 2 deficiency affects the engagement of DNA double-strand break repair pathways following DNA damage
Checkpoint kinase 2 (CHK2) participates in the DNA damage response (DDR) by regulating the cell cycle or inducing apoptosis, and its abnormal activity can lead to cancer development. CHK2 loss-of-function mutations correlate with the onset of many types of tumors and with therapy resistance. As the exact molecula...
Carmen Muñoz-Maldonado, Rahel Etter, Aurélie Quintin et al.
· Cell Death Discovery · 0 citations