M. Chu

Multi-tiered in silico evaluation identifies Sarsasapogenin as a promising ERα-targeted phytochemical against breast cancer.

Sarsasapogenin, a spirostanol sapogenin with reported activity against ERα-positive breast cancer cells, has no defined molecular target, and its metabolic fate has not been considered in computational studies of this compound class. Network pharmacology, biotransformation profiling, and multi-level molecular modeling...

Mechanistic insights into daidzin from Glycine max against breast cancer via network pharmacology and multi-level molecular modeling

An integrated in silico strategy combining network pharmacology and molecular modeling is used to prioritize daidzin targets and validate key interactions, with sirtinol as a reference compound, and prioritize a daidzin-MMP9 axis for experimental validation.

A novel DREB transcription factor enhances salt tolerance in peanut (Arachis hypogaea L.) through upregulation of AhP5CR and AhBADH, leading to increased osmolyte accumulation