A high-throughput imaging pipeline for high-fidelity reconstruction of whole mouse hearts is presented, compatible with endogenous fluorescent reporters and whole-mount staining, allowing, for example, the reconstruction of the cardiac sympathetic nervous system throughout the intact mouse organ.
F. Giardini, C. Palandri, Sofia Botti et al.· Journal of Physiology· 0 citations
AIMS
Fibroblasts are mesenchymal cells in the healthy vascular adventitia. In atherosclerosis, single-cell sequencing datasets suggest fibroblasts are abundant in plaques. However, their identity, origin, and fate during plaque progression remain unclear, which we aim to unravel here.
APPROACH AND RESULTS
To robustly...
Guan-Liang Li, S. Asselberghs, Bai-Xue Yu et al.· Cardiovascular Research· 0 citations
Ischemic heart disease is the main cause of death in developed countries, and full recovery remains unachievable. A potential cure can be based on utilizing miRNAs capable of triggering cardiac regeneration by stimulating cardiomyocyte proliferation. However, to deliver miRNAs efficiently, nanocarriers are required for...
H. Genedy, T. Delair, Josef Huntington et al.· International Journal of Bio...· 0 citations
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