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Author

Max A. Thorwald

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Open access Sep 2026

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiological decline arise. To answer this question, we generated a new mouse model in which mitochondrial mutagenesis can be con...

Sarah J. Shemtov, Eric Hwang, Claire S. Chung et al. · 0 citations
Open access Aug 2026

Form and function of actin impacts actin health and aging

How genetic and pharmacologic perturbations of actin structure and function influence lifespan and various hallmarks of aging in Caenorhabditis elegans is interrogated, providing a comprehensive and publicly accessible resource that maps, for the first time, how changes in actin integrity correlate with diverse aging p...

Maxim Averbukh, Hunter T. Nelson, Tiffany Wang et al. · 2 citations
Open access Aug 2026

Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity

It is shown that the neuronal expression of the chromatin reader BET-1 promotes longevity and resilience in C. elegans through signaling mechanisms involving master transcription factors HSF-1 and DAF-16 and neurotransmitter UNC-13.

Naibedya Dutta, Daniel Hicks, Edgar Esparza et al. · 0 citations

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