Resistance mechanisms and therapeutic strategies after menin inhibitor failure in acute myeloid leukemia.
INTRODUCTION Menin inhibitors, including the FDA-approved agents revumenib and ziftomenib, have emerged as transformative targeted therapies in acute myeloid leukemia (AML), particularly in KMT2A-rearranged (KMT2Ar) and NPM1-mutated (NPM1m) disease. Despite high initial response rates, durability remains limited, and m...