Maternal Diabetes and a High-Fat Diet Program Transgenerational Dysfunction of the Endocrine Pancreas in Offspring.
BACKGROUND Maternal diabetes and exposure to a high‑fat diet (HFD) disrupt pancreatic development and glucose homeostasis, potentially inducing transgenerational metabolic changes. OBJECTIVE Investigate how maternal diabetes and HFD exposure impact the endocrine pancreas across generations. Elucidate their effects on...