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Author

Mayte Suarez-Farinas

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Sep 2026

Safety and Biomarker Analysis of NRG-LU004: Phase I Trial of Accelerated or Conventionally Fractionated Radiotherapy Combined With Durvalumab in PD-L1 High Locally Advanced Non-Small Cell Lung Cancer

Background. Patients with advanced non-small cell lung cancer (NSCLC) and high PD-L1 (>50%) expression show improved outcomes with immune checkpoint inhibitors compared to chemotherapy. We hypothesized that concurrent durvalumab and radiotherapy (RT) without concurrent chemotherapy would be safe and feasible in patient...

Steven H. Lin, S. L. Pugh, D. D. Del Valle et al. · 0 citations
Open access Aug 2026

Rigosertib Reverses Hypertrophic Cardiomyopathy in Noonan Syndrome

It is suggested rigosertib normalizes and reverses RASopathy-associated HCM and other NS-associated syndromic features, supporting its development as a promising treatment for RAF1-associated HCM and, potentially, other RASopathy-dependent pathologies.

Levi Legler, K. Marchetti, Bing Xu et al. · 0 citations
Open access Jul 2026

The Immune Signatures Data Resource 2.0: An Expanded Compendium of Systems Vaccinology Datasets 2304506

An expanded and standardized framework that harmonizes human systems vaccinology datasets using ImmPort metadata, and develops an automated pipeline to integrate experimental design, clinical metadata and serological response data from ImmPort with linked transcriptional profiling data from GEO is presented.

Jian Xing, Gisela Gabernet, Anthony Melillo et al. · 0 citations

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