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Author

Mayumi Ikeda-Imafuku

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Open access 2026

Ionic liquid-based drug delivery systems for overcoming biological barriers and their therapeutic applications

The use of ionic liquids (ILs) has increased substantially in the pharmaceutical industry owing to their inherent tunability and unique physicochemical properties. ILs offer several advantages in drug development, including...

Tatsuya Fukuta, Rikuto Ihara, Anna Suzuki-Okishima et al. · 0 citations
Sep 2026

Structure-biodistribution relationships of chemically and physically modified albumin: a systematic approach to organ-specific drug delivery.

Human serum albumin (HSA) undergoes post-translational modifications that alter its receptor recognition and biodistribution. While HSA receptors such as gp18, gp30, cubilin, and megalin regulate HSA distribution, the relationship between HSA structural changes and organ-specific targeting remains poorly understood. In...

Mirai Nakakita, Maichi Hama, Aiko Hashimoto et al. · 0 citations
Jul 2026

Development of Small Interfering RNA-Loaded Extracellular Vesicles via a High-Pressure Homogenization Approach.

The applicability of using HPH to prepare siRNA-loaded EVs and their subsequent cytoplasmic siRNA delivery is reported, suggesting, for the first time, that HPH holds potential for the development of siRNA-loaded EV therapeutics that could be useful for cytoplasmic siRNA delivery.

Tatsuya Fukuta, Masato Miyazaki, Taiki Fujimoto et al. · 0 citations

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