Author

Md. Abul Hassan Samee

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Open access Jul 2026

Kernelized approach enables explainable gene prioritizations for complex traits

K-PoPS provides a post hoc framework for examining and interpreting GWAS effector-gene nominations by decomposing each prediction into contributions from training genes, and identifies multiple plausible effector genes within a dilated cardiomyopathy locus contrary to the parsimonious assumption.

Tao-Tao Tan, M. Samee · bioRxiv · 0 citations

Open access Jul 2026

SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell Conditions

Single-cell transcriptomics has enabled systematic profiling of cellular states across ordered biological contexts, including developmental stages, treatment phases, disease progression, and anatomical compartments. A central challenge is to reconstruct trajectories that respect the directionality imposed by biology or...

Shifeng Wu, W. C. Walker, Carolyn A. Martin et al. · bioRxiv · 0 citations