Md Anisur Rahman Bhuiyan

New Insights into Binding of G-segment DNA to the Active Site of Escherichia coli Topoisomerase III

Escherichia coli topoisomerase III (EcTopo3) is a type IA topoisomerase that binds single-stranded DNA (ssDNA) during DNA cleavage and strand passage. Here, we report five crystal structures of EcTopo3 in complex with distinct 8-base ssDNA oligonucleotides at 1.85–2.22 Å resolution. These structures reveal a previously...