Integrative Multi-Omics and Humanized Mouse Modelling to Predict Immunotherapy Response in Triple-Negative Breast Cancer.
INTRODUCTION Triple-Negative Breast Cancer (TNBC) is an aggressive variant of breast cancer, which has a high degree of molecular heterogeneity, essentially immunologically cold tumor phenotypes, and heterogeneous responses to immunotherapy. Although immune checkpoint inhibitors and combination immunotherapeutic approa...