Similar to viral hepatitis in humans, paracetamol causes liver damage. Recent developments indicate that traditional plants have been used to treat hepatotoxicity. The current study has been performed to investigate the effectiveness of Lannea coromandelica (LC) bark in reducing the hepatotoxicity caused by paracetamol in rats due to its application in folk medicine. Rats (150–200 g) were split up into 5 groups (n=6). Paracetamol (600 mg/kg body weight) was given once daily for a week, causing acute hepatotoxicity, while the plant extract under investigation was taken orally at 250 and 500 mg/kg body weight for the duration of the experiment. As is customary for hepatoprotective medications, silymarin (100 mg/kg b.w.) was administered orally. Hepatoprotection was ascertained by estimating biochemical indicators such as ALT, AST, ALP, total protein, albumin and globulin level.Treatment with LC extracts significantly attenuated the increased plasma levels of ALT (p<0.05), AST (p<0.05) and ALP (p<0.001) level whereas insignificantly improved total protein, albumin and globulin level. The extract insignificantly progressed the body weight and significantly increased the liver weight (p<0.05) as compared to the disease control animals. The estimated biomarkers provide evidence that the Lannea coromandelica bark extract has shown hepatoprotective activity against paracetamol induced hepatotoxicity in rats.
Bangladesh Pharmaceutical Journal 29(2): 254-260, 2026 (July)
Md Rashed Hossen, Khaleda Nahid, M. Rahman et al.· Bangladesh Pharmaceutical Jo...· 0 citations
Trichoderma species are widely investigated and commercially applied as eco-friendly biocontrol agents in sustainable agriculture. These filamentous fungi protect plants through multiple complementary mechanisms, including mycoparasitism, antibiosis, competition for nutrients and ecological niches, and induction of systemic resistance in host plants. These activities are mediated by a diverse array of secondary metabolites, hydrolytic enzymes, and signaling pathways that collectively suppress pathogens and enhance plant health. Beyond disease control, selected Trichoderma strains promote plant growth by improving nutrient acquisition, modulating phytohormone signaling, and increasing tolerance to abiotic stresses. This review summarizes recent advances in the mechanisms underlying Trichoderma spp. mediated biocontrol, with particular emphasis on secondary metabolites, formulation strategies, commercialization, and field applications. Commercial products are available in various formulations, including wettable powders, granules, and liquid preparations, and have demonstrated efficacy against several economically important plant diseases under field conditions. However, their performance remains highly dependent on strain characteristics, host species, environmental conditions and agricultural practices, resulting in inconsistent efficacy across agroecosystems. Recent progress in genomics, transcriptomics, and metabolomics has substantially improved our understanding of Trichoderma–plant–pathogen interactions and revealed considerable strain-specific variation in biocontrol and plant growth-promoting traits. Future research should prioritize strain-specific optimization, formulation stability, microbiome-informed applications, and improved field predictability. Overall, Trichoderma spp. Represents a valuable component of integrated disease management, offering an effective and sustainable alternative to synthetic pesticides.
Sidratul Muntaha Binta Anam Otithi, Md. Sohel Rana, M. Islam et al.· Plants· 0 citations