Meenakshi Mansukhani

Chlorpyrifos exposure remodels the spermatogenic niche and alters testicular epigenetic dynamics in the absence of overt reproductive toxicity.

Findings reveal that chronic CPF exposure induces early remodeling of the spermatogenic niche and alters testicular epigenetic regulation prior to overt reproductive dysfunction, identifying the Sertoli cell-extracellular matrix axis as a potential early target underlying CPF-induced testicular toxicity.