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Author

Megan Detels

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Open access Sep 2026

Rescue of Proteus syndrome lethality in mice with prenatal miransertib treatment.

PURPOSE Proteus syndrome is caused by constitutive AKT1 activation, resulting in severe overgrowth and tumor susceptibility. We developed a mouse model, featuring endogenously regulated, mosaic expression of the Akt1 c.49G>A, p.(Glu17Lys) (Akt1 E17K) variant. Prior results showed that ubiquitous Akt1E17K expression cau...

Shaima Raji Abdul Rahiman Sirajuddeen, M. Lindhurst, Megan Detels et al. · 0 citations

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