Author

Megan Iminitoff

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Open access Sep 2026

Magel2 deficiency drives microglial synaptic engulfment and alters neuron-microglia interactions in Prader-Willi syndrome

Prader–Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hypothalamic dysfunction, developmental delay, hyperphagia, and cognitive impairment, yet the cellular mechanisms underlying circuit abnormalities remain unclear. Here, we show that loss of the imprinted gene Magel2 remodels microglial state...

Jemima Helen, M. C. Wimmer, Berkan Kanmaz et al. · bioRxiv · 0 citations

Open access Oct 2026

SMCHD1 is a target for gene activation therapy to treat Prader-Willi syndrome

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by loss of expression from the active paternal allele at an imprinted cluster on chromosome 15. Current treatments address individual symptoms rather than the underlying cause of disease. Because all patients preserve a normal but epigenetically silenc...

Megan Iminitoff, Anna Le Fevre, Tamara Cameron et al. · Science Advances · 0 citations