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Megan S. Gant

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Review Open access Sep 2026

Proteoforms in Disease: Biomedical Applications of Top-Down Proteomics.

The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post-translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)-based proteomics has emerged as an essential technique for elucidating this mo...

Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant et al. · 1 citation

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